Expression of Cd10 as a Prognostic and Predictive Factor in Urothelial Carcinomas

Purpose: The aim of the study is to compare the expression of CD10 in invasive and non-invasive urothelial carcinomas. Methods: Primary sites of 40 cases of urothelial carcinomas were studied on H&E stained sections from the original biopsy paraffin block, out of them, 20 with and another 20 – without smooth muscle invasion. For CD 10 expression routine immunohistochemical procedure was applied, using DAKO FLEX monoclonal mouse antihuman clon 56C6. Results: Two groups invasive and non-invasive urothelial cancers were compared in regard to CD10 expression. The results definitely reveal that most of the cells in all invasive cancers express CD10, while in non-invasive cancers CD10 expresion was absent. Conclusion: The results provide convinsing evidense for CD10 role in urothelial cancer invasiveness in underlying smooth muscle.